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He's been dubbed the "sexiest man on the planet," one of the most profitable actors in Hollywood and even a talented director.
But, even with all the accolades, George Clooney hasn't rested on his laurels. He's converted some of his Hollywood pulling power into a number of social causes ranging from human rights to global poverty.
An issue that Clooney is particularly passionate about is the crisis in the Darfur region of Sudan.
Clooney has been campaigning since 2006 for a peaceful resolution of the conflict that has led to the deaths of about 300,000 people, according to the United Nations.
In 2007, Clooney spoke at a "Save Darfur" event in Washington D.C. to raise awareness of the issue and he has even used his name recognition to push world leaders to take action.
While many Americans may not have known what was happening in the region, Clooney helped bring the conflict into living rooms around the country. Clooney produced a TV documentary called "A Journey to Darfur" which advocated for action.
In December 2007, along with fellow actor Don Cheadle, Clooney was presented with the Summit Peace Award by the Nobel Peace Prize Laureates for his work around the Darfur crisis.
The following month, Clooney was made a messenger of peace by the United Nations. Today, Clooneyhas joined human rights activist and author John Prendergast to continue raising awareness of the conflict.
Here's your chance to quiz one of Hollywood's most interesting figures in both the acting world and human rights arena.